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TVP Bliss 客座教授
发布时间:2019年11月19日 06:22 |浏览:次



1959-1967 McGill University, Montreal, Canada

BSc (Physiology) 1963; PhD 1967


1967-2006 Member of Scientific Staff

Medical Research Council
National Institute for Medical Research
1988-2006 Head, Division of Neurophysiology, NIMR
1990-present  Visiting Professor, University College London
1996-2006 Head, Neurosciences Group, NIMR 2006-present   Visiting worker, Division of Neurophysiology, NIMR
2009-2013 Adjunct Professor, Seoul National University
Honours 1991 Bristol Myers Squibb Award for Neuroscience (with ER Kandel)
1994 Feldberg Prize
1994 Fellow of the Royal Society
1998 Founding Fellow of the Academy of Medical Sciences
2003 Annual Award for Contributions to British Neuroscience, British Neuroscience Society
2012 Croonian Prize Lecture, Royal Society (this is the Society’s principal lecture in the biological sciences, given annually since 1738).
2013 Ipsen Prize for Neuronal Plasticity; Hon LlD Dalhousie University
2014 Hon DSc University of Hertfordshire

2014 Member Acadamia Europaea

Scientific Advisory Committees: 

 Centre for Synaptic Plasticity, University of Bristol (Chair), Feldberg Foundation (UK and Germany), Lister Foundation (UK), Fondation Louis Jeantet, Geneva.

Research Interests. 

Neural basis of learning and memory, with particular reference to the mechanisms and function of long-term potentiation in the hippocampus

Tim Bliss was born in England and gained his PhD at McGill University in Canada.  In 1967 he joined the MRC National Institute for Medical Research in Mill Hill, London, where he was Head of the Division of Neurophysiology from 1988 till 2006.   His work with Terje L?mo in Per Andersen’s laboratory at the University of Oslo in the late 1960’s established the phenomenon of long-term potentiation (LTP) as the dominant synaptic model of how the mammalian brain stores memories.  Since then he has worked on many aspects of LTP, including presynaptic mechanisms responsible for the persistent increase in synaptic efficacy that characterizes LTP, and the relationship between synaptic plasticity and memory.  He is a Fellow of the Royal Society, and of the Academy of Medical Sciences. He shared the Bristol Myers Squibb award for Neuroscience with Eric Kandel in 1991, and the Ipsen Prize for Neural Plasticity with Richard Morris and Yadin Dudai in 2013.  In 2011 he received an honorary degree from Dalhousie University. In May 2012 he gave the annual Croonian Lecture at the Royal Society on ‘The Mechanics of Memory’.
Tim Bliss, H factor=50; total citation 21028; one of his major review in Nature was cited 7028 time.

TVP Bliss

1. Popov, VI, Davies HA, Vadim V. Rogachevsky VV, Il’ya V. Patrushev IV, Michael L. Errington ML,  Paul L. A. Gabbott  PLA,, Timothy V. P. Bliss TVP, and Stewart MG (2004) Remodelling of synaptic morphology but unchanged synaptic density during late phase LTP: a serial section EM study of the dentate gyrus in the anaesthetised rat. Neuroscience 128:251-62
2. O’Connor V, Houtman SH, De Zeeuw CI, Bliss TV, French PJ (2004).  Eml5, a novel WD40 domain protein expressed in rat brain. Gene. 336:227-37
3. Rodriguez JJ, Davies HA, Silva AT, De Souza IE, Peddie CJ, Colyer FM, Lancashire CL, Fine A, Errington ML, Bliss TV, and Stewart MG. (2005)Long-term potentiation in the rat dentate gyrus is associated with enhanced Arc/Arg3.1 protein expression in spines, dendrites and glia. Eur J Neurosci. 9:2384-96.
4. Ris L, Angelo M, Plattner F, Capron B, Errington ML, Bliss TV, Godaux E,Giese KP. Sexual dimorphisms in the effect of low-level p25 expression on synaptic plasticity and memory (2005) Eur J Neurosci. 21:2384-2396.
5. Fragkouli A, Hearn C,  Errington ML, Cooke S,  Grigoriou M, Bliss T, Stylianopoulou F and Pachnis V. (2005) Loss of forebrain cholinergic neurons and impairment in spatial learning and memory in LHX7-deficient mice. Eur Journal of Neurosci 21: 2923-2938.
6. O’Doherty A, Ruf S, Mulligan C, Hildreth V, Errington ML, Cooke S, Sesay A, Modino S, Vanes L, Hernandez D, Linehan JM, Sharpe PT, Brandner S, Bliss TV, Henderson DJ, Nizetic D, Tybulewicz VL, Fisher EM (2005) An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science 309:2033-2037.
7. Cooke SF, Wu J, Plattner F, Errington M, Rowan M, Peters M, Hirano A,
Bradshaw KD, Anwyl R, Bliss TV, Giese KP (2006)  Autophosphorylation of alphaCaMKII is not a general requirement for NMDA receptor-dependent LTP in the adult mouse. J Physiol. 574:805-18
8. Plath N, Ohana O, Dammermann B, Errington ML, Schmitz D, Gross C, Mao X, Engelsberg A, Mahlke C, Welzl H, Kobalz U, Stawrakakis A, Fernandez E, Waltereit R, Bick-Sander A, Therstappen E, Cooke SF, Blanquet V, Wurst W, Salmen B, Bosl MR, Lipp HP, Grant SG, Bliss TV, Wolfer DP, Kuhl D. (2006) Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron. 52:437-44.
9. Ward BC, McGuinness, L., Akerman C, Fine A, Bliss TVP,  Emptage NJ (2006)  State-dependent mechanisms of LTP expression revealed by optical quantal analysis. Neuron. 52:649-661.
10. Rodríguez JJ, Davies HA, Errington ML, Verkhratsky A, Bliss TV, Stewart MG. (2008) ARG3.1/ARC expression in hippocampal dentate gyrus astrocytes: ultrastructural evidence and co-localization with glial fibrillary acidic protein. J Cell Mol Med. 12:671-8.
11. Morice E, Andreae LC, Cooke SF, Vanes L, Fisher EM, Tybulewicz V, Bliss TV (2008) Preservation of long-term memory and synaptic plasticity despite short-term impairments in the
Tc1 mouse model of Down syndrome. Learn Mem 15:492-500.
12. Galante M, Jani H, Vanes L, Daniel H, Fisher EM, Tybulewicz VL, Bliss TV,Morice E (2009) Impairments in motor coordination without major changes in cerebellar
plasticity in the Tc1 mouse model of Down syndrome. Hum Mol Genet. 18:1449-63.
13. Chen PE, Errington ML, Kneussel M, Chen G, Annala AJ, Rudhard YH, Rast GF,Specht CG, Tigaret CM, Nassar MA, Morris RG, Bliss TV, Schoepfer R (2009) Behavioral
deficits and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampus. Learn Mem. 16:635-44.

14. DREAM controls the on/off switch of specific activity-dependent transcription pathways (2014) Mellstrom B, Sahun I, Ruiz-Nuno A, Murtra P, Gomez-Villafuertes R, Savignac M, Oliveros JC, Gonzalez P, Kastanauskaite A, Knafo S, Zhuo M, Higurera-Matas A, Errington ML, Maldonado R, DeFelipe J, Jefferys JG, Bliss TV, Dierssen M, Naranjo JR. Mol Cell Biol 34:877-887.


Bliss, T.V.P., Collingridge, G.L. & Morris, R.G.M. (Eds) (2004) Long-term potentiation: enhancing neuroscience for thirty years. Oxford University Press.
Andersen P, Morris RGM,  Amaral D,  Bliss TVP, O’Keefe J (Eds) (2007) The Hippocampus Book. Oxford University Press, New York.
Reviews, Commentaries and Book chapters
1. Cooke SF and Bliss TV (2005) Long-term potentiation and cognitive drug discovery. Curr Opin Investig Drugs. 61:25-34.
2 Cavazzini M, Bliss T, Emptage N (2005) Ca2+ and synaptic plasticity. Cell Calcium 38:355-367.
3 Cooke SF, Bliss TV (2006) Plasticity in the human central nervous system.Brain. 129:1659-73.
4 Bliss TV, Collingridge GL, Laroche S(2006) Neuroscience. ZAP and ZIP, a story to forget.
Science. 313:1058-9.
5 Bliss TVP, Collingridge GL, Morris RGM (2006) Synaptic Plasticity in the Hippocampus. In The Hippocampus Book (Ed. Andersen P, Morris R, Amaral D, Bliss T, O’Keefe J. New York, Oxford University Press. Ch. !0 Synaptic Plasticity in the Hippocampus pp 343-474
6. Neves G, Cooke SF, Bliss TVP (2008) Synaptic plasticity, memory and the hippocampus; a neural network approach to causality. Nature Reviews Neuroscience 9:65-75
7.  Bliss TVP, Cooke SF (2011)  Long-term potentiation and long-term depression: a clinical perspective. Clinics (Sao Paulo) 66 Suppl 1:3-17.
8.  Bliss TVP, Collingridge GL (2013)  Expression of NMDA receptor-dependent LTP in the hippocampus: bridging the divide. Mol Brain. Jan 22;6:5. doi: 10.1186/1756-6606-6-5.
9. Bliss TVP, Collingridge GL, Morris RG (2013) Synaptic plasticity in health and disease: introduction and overview. Philos Trans R Soc B Biol Sci. Dec 2 doi:10.1098/rstb.2013.0129.


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